In vitro biological evaluation of novel 7-O-dialkylaminoalkyl cytotoxic pectolinarigenin derivatives against a panel of human cancer cell lines

…, R Tundis, B Deguin, MR Loizzo, F Menichini…

Index: Bonesi, Marco; Tundis, Rosa; Deguin, Brigitte; Loizzo, Monica R.; Menichini, Federica; Tillequin, Francois; Menichini, Francesco Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 20 p. 5431 - 5434

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Citation Number: 12

Abstract

The effect of novel pectolinarigenin derivatives bearing a dialkylaminoalkyl substituent at O- 7 on cell proliferation was evaluated in vitro in a panel of seven human cancer cell lines including renal adenocarcinoma ACHN, amelanotic melanoma C32, colorectal adenocarcinoma Caco-2, lung large cell carcinoma COR-L23, malignant melanoma A375, lung carcinoma A549 and hepatocellular carcinoma Huh-7D12 cell lines. Pectolinarigenin ...