A heterocyclic molecule with significant activity against dengue virus

V Nair, G Chi, Q Shu, J Julander, DF Smee

Index: Nair, Vasu; Chi, Guochen; Shu, Qingning; Julander, Justin; Smee, Donald F. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 5 p. 1425 - 1427

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Citation Number: 26

Abstract

There are no specific approved drugs or vaccines for the treatment or prevention of infectious dengue virus and there are very few compounds known that inhibit the replication of this virus. This letter describes the concise synthesis of two uracil-based multifunctional compounds. One of these compounds (1) has strong activity against dengue virus. It also exhibits low activity against a few other RNA viruses, but is highly active against yellow ...