Synthesis and biological evaluation of a new series of ebselen derivatives as glutathione peroxidase (GPx) mimics and cholinesterase inhibitors against Alzheimer's …

Z Luo, L Liang, J Sheng, Y Pang, J Li, L Huang…

Index: Luo, Zonghua; Liang, Liang; Sheng, Jianfei; Pang, Yanqing; Li, Jianheng; Huang, Ling; Li, Xingshu Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 4 p. 1355 - 1361

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Citation Number: 24

Abstract

Abstract A series of ebselen derivatives were designed, synthesised and evaluated as inhibitors of cholinesterases (ChEs) and glutathione peroxidase (GPx) mimics. Most of the compounds were found to be potent against AChEs and BuChE, compounds 5e and 5i, proved to be the most potent against AChE with IC 50 values of 0.76 and 0.46 μM, respectively. Among these hybrids, most of the compounds were found to be good GPx ...