Tetrahydroisoquinoline-3-carboxylate based matrix-metalloproteinase inhibitors: design, synthesis and structure–activity relationship
…, M Schudok, W Schwab, W Thorwart, D Barbier…
Index: Matter, Hans; Schudok, Manfred; Schwab, Wilfried; Thorwart, Werner; Barbier, Denis; Billen, Guenter; Haase, Burkhard; Neises, Bernhard; Weithmann, Klaus-Ulrich; Wollmann, Theo Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 11 p. 3529 - 3544
Full Text: HTML
Citation Number: 49
Abstract
The design, synthesis and structure–activity relationship (SAR) of a series of nonpeptidic 2- arylsulfonyl-1, 2, 3, 4-tetrahydro-isoquinoline-3-carboxylates and-hydroxamates as inhibitors of the matrix metalloproteinase human neutrophil collagenase (MMP-8) is described here. Based on available X-ray structures of MMP-8/inhibitor complexes, our structure-based design strategy was directed to complement major protein-ligand interaction regions ...
Related Articles:
[Desmarets, Christophe; Omar-Amrani, Rafik; Walcarius, Alain; Lambert, Jacques; Champagne, Benoit; Fort, Yves; Schneider, Raphael Tetrahedron, 2008 , vol. 64, # 2 p. 372 - 381]
Direct catalytic cross-coupling of organolithium compounds
[Giannerini, Massimo; Fananas-Mastral, Martin; Feringa, Ben L. Nature Chemistry, 2013 , vol. 5, # 8 p. 667 - 672]
Palladium-catalyzed Suzuki cross-coupling of arylhydrazines via C NHNH 2 bond activation in water
[Liu, Jin-Biao; Zhou, He-Ping; Peng, Yi-Yuan Tetrahedron Letters, 2014 , vol. 55, # 17 p. 2872 - 2875]
[Ju, Jinhun; Nam, Hyungoog; Jung, Hyun Min; Lee, Sunwoo Tetrahedron Letters, 2006 , vol. 47, # 49 p. 8673 - 8678]
Oxovanadium (v)-catalyzed oxidative biaryl synthesis from organoborate under O 2
[Mizuno, Hidenori; Sakurai, Hidehiro; Amaya, Toru; Hirao, Toshikazu Chemical Communications, 2006 , # 48 p. 5042 - 5044]