Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design
IC Choong, W Lew, D Lee, P Pham…
Index: Ueda; Okamoto; Tsuji; Muraoka Chemical and pharmaceutical bulletin, 1968 , vol. 16, # 12 p. 2355 - 2361
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Citation Number: 123
Abstract
... 23), pp 5005–5022. DOI: 10.1021/jm020230j. Publication Date (Web): October 15, 2002. Copyright © 2002 American Chemical Society. ... of their roles in inflammation and apoptosis, the caspases have generated substantial interest from both the pharmaceutical and the ... Chemistry. ...
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