Design of Novel Potent Antihyperlipidemic Agents with Antioxidant/Anti-inflammatory Properties: Exploiting Phenothiazine's Strong Antioxidant Activity
AN Matralis, AP Kourounakis
Index: Matralis, Alexios N.; Kourounakis, Angeliki P. Journal of Medicinal Chemistry, 2014 , vol. 57, # 6 p. 2568 - 2581
Full Text: HTML
Citation Number: 11
Abstract
Because atherosclerosis is an inflammatory process involving a series of pathological events such as dyslipidemia, oxidative stress, and blood clotting mechanisms, we hereby report the synthesis and evaluation of novel compounds in which antioxidant, anti- inflammatory, and squalene synthase (SQS) inhibitory/hypolipidemic activities are combined in simple molecules through design. The coupling of two different pharmacophores ...
Related Articles:
[Synthesis in the phenothiazine series.]
[Profft,E.; Kasper,F. Arzneimittel Forschung, 1962 , vol. 12, p. 48 - 52]
[Synthesis in the phenothiazine series.]
[Profft,E.; Kasper,F. Arzneimittel Forschung, 1962 , vol. 12, p. 48 - 52]