Organic Letters 2008-02-07

Total synthesis of 7-deoxypancratistatin-1-carboxaldehyde and carboxylic acid via solvent-free intramolecular aziridine opening: phenanthrene to phenanthridone cyclization strategy.

Jonathan Collins, Melissa Drouin, Xuetong Sun, Uwe Rinner, Tomas Hudlicky

Index: Org. Lett. 10(3) , 361-4, (2008)

Full Text: HTML

Abstract

Solid-state silica-gel-catalyzed opening of aziridine 6 provided phenanthrene 7, whose oxidative cleavage, recyclization, and further elaboration furnished the C-1 aldehyde and carboxylic acid derivatives of 7-deoxypancratistatin for potential analogue synthesis.

Related Compounds

Related Articles:

Molecular design, synthesis and docking study of benz[b]oxepines and 12-oxobenzo[c]phenanthridinones as topoisomerase 1 inhibitors.

2009-05-01

[Bioorg. Med. Chem. Lett. 19 , 2444-7, (2009)]

Novel isoquinolinone-derived inhibitors of poly(ADP-ribose) polymerase-1: pharmacological characterization and neuroprotective effects in an in vitro model of cerebral ischemia.

2003-06-01

[J. Pharmacol. Exp. Ther. 305(3) , 943-9, (2003)]

PARP-1 inhibition prevents CNS migration of dendritic cells during EAE, suppressing the encephalitogenic response and relapse severity.

2011-07-01

[Mult. Scler. 17(7) , 794-807, (2011)]

A novel spectrophotometric method for determination of kinetic constants of aldehyde oxidase using multivariate calibration method.

2008-04-24

[J. Biochem. Biophys. Methods 70(6) , 999-1005, (2008)]

Stereoselective synthesis of functionalised carbocyclic amides: construction of the syn-(4aS,10bS)-phenanthridone skeleton.

2012-05-21

[Org. Biomol. Chem. 10(19) , 3937-45, (2012)]

More Articles...