Biological Psychiatry 2012-11-01

Pre- and postsynaptic serotonergic differences in males with extreme levels of impulsive aggression without callous unemotional traits: a positron emission tomography study using (11)C-DASB and (11)C-MDL100907.

AngelaJ Rylands, Rainer Hinz, Matthew Jones, SophieE Holmes, Maria Feldmann, Gavin Brown, AdamW McMahon, PeterS Talbot

Index: Biol. Psychiatry 72(12) , 1004-11, (2012)

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Abstract

Impulsive aggression (IA) in adults is associated with brain serotonin (5-HT) system abnormalities and is more common following childhood adversity. Within aggressive behavior, IA and callous unemotional (CU) traits are core components of differentiable factors with opposing 5-HT abnormalities. We aimed to investigate 5-HT abnormalities in IA and potential correlations with severity of childhood adversity while controlling for confounding 5-HT effects of high CU traits and mental disorders.

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