Immobilised Candida antarctica B as efficient catalyst for the synthesis of local anaesthetic intermediates

…, MP Masia, M Marchetti, R Morrone, M Solinas

Index: Giunta, Daniela; Masia, Maria Paola; Marchetti, Mauro; Morrone, Raffaele; Solinas, Maurizio Tetrahedron Letters, 2013 , vol. 54, # 37 p. 5122 - 5125

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Citation Number: 5

Abstract

Abstract We hereby present the development of new reaction conditions for the CALB catalysed esterification of substituted benzoic acids. Using cyclohexane as the reaction media a number of heptyl benzoates have been easily isolated in good to excellent yields (up to 100% at 80 C, 20–24 h). Moreover, the catalytic system has been successfully applied to the synthesis of local anaesthetics intermediates also showing good productivity in ...