The Diacylation of Amides by Acyl Chloride—Pyridine Compounds

QE Thompson

Index: Thompson Journal of the American Chemical Society, 1951 , vol. 73, p. 5841,5844

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Citation Number: 43

Abstract

A novel acylation of amides has been reported in which amides of the type RCONH2 react with two molecules of acyl chloride-pyridine addition compound at low temperatures to give the corresponding triacylated ammonias in good yields. Evidence is presented which indicates that this acylation is a true “diacylation” and does not involve the intermediate forma-tion of a secondary amide. Seventeen acid chlorides have been investigated to ...