Synthesis and cytotoxic evaluation of 6-(3-pyrazolylpropyl) derivatives of 1,4-naphthohydroquinone-1,4-diacetate.
Aurora Molinari, Alfonso Oliva, Claudia Ojeda, José M Miguel del Corral, M Angeles Castro, Carmen Cuevas, Arturo San Feliciano
Index: Arch. Pharm. (Weinheim) 342(10) , 591-9, (2009)
Full Text: HTML
Abstract
Several new 6-(3-pyrazolylpropyl) derivatives of 1,4-naphthohydroquinone-1,4-diacetate (NHQ-DA) have been prepared by chemical modifications of the Diels-Alder adduct of alpha-myrcene and 1,4-benzoquinone. All these new compounds and precursors have been evaluated in vitro for their cytotoxicity against cultured human cancer cells of MB-231 breast-adeno carcinoma, A-549 lung carcinoma, and HT-29 colon carcinoma. GI(50) values ranged in and below the micromolar concentration level.
Related Compounds
Related Articles:
2009-03-01
[Eur. J. Med. Chem. 44 , 1086-92, (2009)]
A laccase-catalysed one-pot synthesis of aminonaphthoquinones and their anticancer activity
2012-07-15
[Bioorg. Med. Chem. 20(14) , 4472-81, (2012)]
Dual effects of superoxide dismutase on the autoxidation of 1,4-naphthohydroquinone.
1990-01-01
[Free Radic. Biol. Med. 8(1) , 21-4, (1990)]
Autoxidation of naphthohydroquinones: effects of metals, chelating agents, and superoxide dismutase.
1997-01-01
[Free Radic. Biol. Med. 22(4) , 689-95, (1997)]
1995-01-01
[Arch. Toxicol. 69(6) , 362-7, (1995)]