Antiviral Activity of Various 1-(2′-Deoxy-β-d-lyxofuranosyl), 1-(2′-Fluoro-β-d-xylofuranosyl), 1-(3′-Fluoro-β-d-arabinofuranosyl), and 2′-Fluoro-2′, 3′-didehydro …

…, N Shakya, M Mak, B Agrawal, DL Tyrrell…

Index: Srivastav, Naveen C.; Shakya, Neeraj; Mak, Michelle; Agrawal, Babita; Tyrrell, D. Lorne; Kumar, Rakesh Journal of Medicinal Chemistry, 2010 , vol. 53, # 19 p. 7156 - 7166

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Citation Number: 17

Abstract

Despite the existence of successful vaccine and antiviral therapies, infection with hepatitis B virus (HBV) continues to be a major global cause of acute and chronic liver disease and high mortality. We synthesized and evaluated several lyxofuranosyl, 2′-fluoroxylofuranosyl, 3′-fluoroarabinofuranosyl, and 2′-fluoro-2′, 3′-didehydro-2′, 3′-dideoxyribose pyrimidine nucleoside analogues for antiviral activities against hepatitis B virus. Among ...