Copper??Catalyzed Cross??Coupling Reactions of Nucleobases with Arylboronic Acids: An Efficient Access to N??Arylnucleobases

Y Yue, ZG Zheng, B Wu, CQ Xia…

Index: Yue, Yang; Zheng, Zhang-Guo; Wu, Bo; Xia, Chuan-Qin; Yu, Xiao-Qi European Journal of Organic Chemistry, 2005 , # 24 p. 5154 - 5157

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Citation Number: 22

Abstract

Abstract An efficient avenue for the direct N-arylation of nucleobases with arylboronic acids that is catalyzed by simple copper salts was discovered. The N-arylnucleobases were obtained in excellent yields at room temperature within 45 min when methanol and water were used as a mixed solvent. Under these conditions, the coupling reaction tolerates both electron-donating and electron-withdrawing substituents at the o-, m-, or p-positions of ...