Organic Letters 2003-10-02

Highly enantioselective catalytic phenylation of ketones with a constrained geometry titanium catalyst.

Celina García, Patrick J Walsh

Index: Org. Lett. 5(20) , 3641-4, (2003)

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Abstract

[reaction: see text] The catalytic asymmetric addition of phenyl groups from diphenylzinc to ketones is reported. The catalyst, generated from a dihydroxy bis(sulfonamide) ligand and titanium tetraisopropoxide, gives good to excellent enantioselectivities with a range of substrates.