Novel naphthyridines are histamine H3 antagonists and serotonin reuptake transporter inhibitors.
Michael A Letavic, John M Keith, Kiev S Ly, Ann J Barbier, Jamin D Boggs, Sandy J Wilson, Brian Lord, Timothy W Lovenberg, Nicholas I Carruthers
Index: Bioorg. Med. Chem. Lett. 17(9) , 2566-9, (2007)
Full Text: HTML
Abstract
A series of novel tetrahydronaphthyridine-based histamine H(3) ligands that have serotonin reuptake transporter inhibitor activity is described. The 1,2,3,4-tetrahydro-2,6-naphthyridine scaffold is assembled via the addition of a nitrostyrene to a metalated pyridine followed by reduction and cyclization to form the naphthyridine. In vitro biological data for these novel compounds are discussed.
Related Compounds
Related Articles:
Synthesis of substituted spiro [4.5] deca-3, 6, 9-triene-2, 8-diones: an expeditious route to the spiro [4.5] decane terpene skeleton. Haack RA and Beck KR.
[Tetrahedron Lett. 30(13) , 16505-8, (1989)]
Synthesis of higenamine, A cardiotonic principle of aconite root. Chang K-C, et al.
[Arch. Pharm. Res. 7(2) , 133-36, (1984)]
1998-06-26
[J. Nat. Prod. 61(6) , 709-12, (1998)]