Effect of 5HT2C-receptor agonist MK-212 on blood corticosterone level and behavior in mice.

E G Kuznetsova, T G Amstislavskaya, V V Bulygina, M A Tibeikina, N K Popova

Index: Bull. Exp. Biol. Med. 142(5) , 594-7, (2006)

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Abstract

A dose-dependent the effect of 5HT2C-receptor agonist MK-212 on mouse behavior was demonstrated. Intraperitoneal injection of MK-212 in high doses (0.5 and 1.0 mg/kg) increased blood level of corticosterone in mice and reduced their motor activity. In low doses of 0.1 and 0.2 mg/kg, the agonist reduced anxiety, but had no effect on motor activity. It is hypothesized that low doses of MK-212 exhibited anxiolytic activity in mice.