Total synthesis of (.+-.)-N2-(phenylsulfonyl)-CPI,(.+-.)-CC-1065,(+)-CC-1065, ent-(-)-CC-1065, and the precise, functional agents (.+-.)-CPI-CDPI2,(+)-CPI-CDPI2, and …
DL Boger, RS Coleman
Index: Boger,D.L.; Coleman,R.S. Journal of the American Chemical Society, 1988 , vol. 110, p. 4796
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Citation Number: 109
Abstract
Abstract: Full details of the total synthesis of (*)-p-(phenylsulfonyl)-CPI (3), the spiro [2.5] octa- 4, 7-dien-6-one bearing left-hand segment of CC-1065, the coupling of the racemic and resolved immediate precursors (&)-(1R*)-33,(-)-(19-33, and (+)-(1R)-33 with synthetic PDE-I dimer (PDE-12, 39), and incorporation into the total syntheses of (i)-CC-1065, natural (+)-CC- 1065, and enantiomeric (-)-CC-1065 are described. The approach to the CC-1065 CPI left ...
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