Potential inhibitors of L-asparagine biosynthesis. 4. Substituted sulfonamide and sulfonylhydrazide analogs of L-asparagine
S Brynes, GJ Burckart, M Mokotoff
Index: Brynes,S. et al. Journal of Medicinal Chemistry, 1978 , vol. 21, p. 45 - 49
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Citation Number: 16
Abstract
Several N-substituted sulfonamides and"-substituted sulfonylhydrazides have been prepared as sulfur analogues of L-asparagine with the potential of acting as inhibitors of L- asparagine synthetase (ASase, from Novikoff hepatoma). L-Cystine was converted in known steps to N-carboxy-3-(sulfonylchloro)-~-alanine dibenzyl ester (1). Condensation of 1 with 0- benzylhydroxylamine, p-(fluorosulfonyl) benzylamine, or monoethyl fumarylhydrazide (S), ...
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