[The stabilization of physostigmine salicylate injection solutions. 2].

D Trose, A Kässmann

Index: Pharmazie 45(10) , 783-5, (1990)

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Abstract

In a long term test covering 4 years the potency of stabilizing agents for 0.04% physostigmine salicylate (1) solutions was studied under thermal loading. Thereby complex stabilizers were used as well as simple stabilizing agents. The most effective stabilization was achieved with 0.1% ascorbic acid. The results of the 1th information concerning the stabilization of a 0.1% 1 injection solution with ascorbic acid over a period of one year were confirmed in a long term test for 0.04% 1 solutions. At the some time these long term tests confirmed the formulation as being established for the "Standard Formulas 1988". The stability tests were carried out spectrophotometricly by using the picrate method. Other methods mentioned in literature gave no satisfying reproducibility.