Synthesis of 3′-O-phosphonoethyl nucleosides with an adenine and a thymine base moiety
Q Huang, P Herdewijn
Index: Huang, Qiuya; Herdewijn, Piet Nucleosides, Nucleotides and Nucleic Acids, 2009 , vol. 28, # 5-7 p. 337 - 351
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Citation Number: 6
Abstract
The synthesis and antiviral evaluation of new 3′-O-phosphonoethyl modified phosphonate nucleosides related to PMDTA and PMDTT is described. The reaction scheme starts from protected L-threose and the phosphonate group is introduced by the Arbuzov reaction. The 2′-OH as well as the 2′-deoxygenated nucleosides have been obtained. Unfortunately, none of these synthesized compounds shows activity against HIV and HCV.
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