Amoxapine-associated acute respiratory distress.

Masaru Ando, Eishi Miyazaki, Ryu-Ichi Takenaka, Toshiyuki Okubo, Osamu Matsuno, Shin-Ichi Nureki, Kazunobu Ito, Tomiyasu Tsuda, Toshihide Kumamoto

Index: Respirology 13(1) , 149-51, (2008)

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Abstract

A 37-year-old woman was admitted to our hospital because of acute respiratory distress. Two weeks previously, amoxapine (75 mg/day) had been administered for the first time. Ten days later she developed a high fever, severe hypoxaemia and pulmonary infiltrates on chest CT, including patchy areas of ground-glass opacity, thickening of the interlobular septae and bronchial walls and pleural effusions. BAL showed a predominance of neutrophils, lymphocytes and erythrocytes but not eosinophils. Amoxapine was stopped, resulting in complete resolution of the pulmonary infiltrates. When the patient was re-exposed to amoxapine (52.5 mg total dose), high fever, reduced SaO(2) and pulmonary infiltrates reappeared. We concluded that acute respiratory distress may be associated with amoxapine treatment.