Synthetic Models of the Active Site of Cytochrome P??450. 1st Communication. The Synthesis of a Doubly??Bridged Iron (II)??Porphyrin Carrying a Tightly Bound Thiolate …

…, H Fretz, U Piantini, WD Woggon

Index: Staeubli, Beat; Fretz, Heinz; Piantini, Umberto; Woggon, Wolf-Dietrich Helvetica Chimica Acta, 1987 , vol. 70, p. 1173 - 1193

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Citation Number: 39

Abstract

Abstract The doubly-bridged iron (II)-tetraphenylporphyrin derivative 6, carrying a sterically fixed S− ligand in the 'proximal'position and the substrate at the 'distal'site, was synthesised as an enzyme model for cytochrome P-450. Compound 36, the CO complex of 6, displays a split Soret band (403 and 457 nm) similar to the native cytochrome P-450.