Scandinavian Journal of Gastroenterology 2012-09-01

Prospective comparative study of endoscopic papillary large balloon dilation and endoscopic sphincterotomy for removal of large bile duct stones in patients above 45 years of age.

Myung Jin Oh, Tae Nyeun Kim

Index: Scand. J. Gastroenterol. 47(8-9) , 1071-7, (2012)

Full Text: HTML

Abstract

Although endoscopic papillary large balloon dilation (EPLBD) with limited endoscopic sphincterotomy (ES) showed excellent outcomes for treatment of large bile duct stones, hemorrhage and recurrence of stones are problematic complications. Recent studies suggest that EPLBD alone is safe and effective for removal of large bile duct stones. This study aimed to determine the therapeutic outcomes and safety of EPLBD, compared with ES, for removal of large bile duct stones.Eighty-three patients above 45 years of age with bile duct stones >1 cm in diameter were randomized to EPLBD and ES groups for removal of common bile duct stones from September 2010 to August 2011. Prophylactic gabexate mesilate was given to all patients.Baseline characteristics were not significantly different, except diabetes and gallbladder stones between the EPLBD group (n = 40) and ES group (n = 43). The overall complete stone removal rate in each group was 97.5% (39/40) and 95.3% (41/43), respectively (p = 0.600). Requirement of mechanical lithotripsy was not significantly different between the EPLBD and ES group (10% vs. 21%, p = 0.171). Complete ductal clearance in one session was achieved in 82.4% and 81.4% of cases in each group, respectively (p = 0.577). There were no differences in complication rates between the EPLBD and ES group; pancreatitis, 5.0% vs. 7.0%; hemorrhage, 10.0% vs. 16.3%; acute cholangitis, 5.0% vs. 2.3%, and perforation, 2.5% vs. 0%.The therapeutic outcomes and complications of EPLBD for removal of large bile duct stones are comparable to those of ES.


Related Compounds

Related Articles:

Involvement of proteinase activated receptor-2 in the vascular response to sphingosine 1-phosphate.

2014-04-01

[Clin. Sci. 126(8) , 545-56, (2014)]

Role of TRPV1 in nociception and edema induced by monosodium urate crystals in rats.

2011-08-01

[Pain 152(8) , 1777-88, (2011)]

Neonatal amygdala lesions advance pubertal timing in female rhesus macaques.

2015-01-01

[Psychoneuroendocrinology 51 , 307-17, (2014)]

The short term satiety peptide cholecystokinin reduces meal size and prolongs intermeal interval.

2011-06-01

[Peptides 32(6) , 1289-95, (2011)]

Effect of a serine protease inhibitor on the progression of chronic renal failure.

2012-10-15

[Am. J. Physiol. Renal Physiol. 303(8) , F1126-35, (2012)]

More Articles...