Bioorganic & medicinal chemistry

Hybrid pharmacophore design and synthesis of isatin–benzothiazole analogs for their anti-breast cancer activity

VR Solomon, C Hu, H Lee

Index: Solomon, V. Raja; Hu, Changkun; Lee, Hoyun Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 21 p. 7585 - 7592

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Citation Number: 153

Abstract

A hybrid pharmacophore approach was used to design and synthesize isatin–benzothiazole analogs to examine their anti-breast cancer activity. The cytotoxicity of these compounds were determined using three different human breast tumor cell lines, MDA-MB231, MDA- MB468, MCF7, and two non-cancer breast epithelial cell lines, 184B5 and MCF10A. Although all compounds examined were quite effective on all the cancer cell lines ...