A Synthesis of dl-Proline from Pyrrole1

FK Signaigo, H Adkins

Index: Signaigo; Adkins Journal of the American Chemical Society, 1936 , vol. 58, p. 1122

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Citation Number: 17

Abstract

However, it is not necessary to assume the existence of tautomeric pyrroles in order to explain the formation of 2-carbethoxypyrrole, for the ethyl chlorocarbonate may condense with the hydrogen on the 2-carbon atom. Such a scheme finds support in the fact that 1- methylpyrrole does not form a Grignard reagent yet condenses with acid chlorides in the presence of an alkylmagnesium halide to yield l-methyl-2-acylpyrroles. 8 However I- ...