Synthesis of N, N-Dialkyl-β-hydroxyamides from N, N-Dialkylamides and Ketones Using Lithium Reagents1

WH Puterbaugh, CR Hauser

Index: Puterbaugh; Hauser Journal of the American Chemical Society, 1953 , vol. 75, p. 2415

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Citation Number: 4

Abstract

The aldol condensation method described previously for preparing@-hydroxy esters from esters and ketones or aldehydes by means of lithium amide has been adapted to the synthesis of N, N-dialkyl-@-hydroxyamides from N, N-dialkylamides and ketones by employing the appropriate lithium dialkylamide. This new method appears to be as satisfactory as the extension of the Reformatsky reaction described by other workers. ...