Infant birth weight and third trimester maternal plasma markers of vascular integrity: the MIREC study.

Premkumari Kumarathasan, Renaud Vincent, Agnieszka Bielecki, Erica Blais, Katrin Blank, Dharani Das, Subramanian Karthikeyan, Sabit Cakmak, Mandy Fisher, Tye Arbuckle, William Fraser

Index: Biomarkers 21 , 257-66, (2016)

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Abstract

There is paucity of information on mechanisms constituting adverse birth outcomes. We assessed here the relationship between vascular integrity and adverse birth effects.Third trimester maternal plasma (n = 144) from the Maternal-Infant Research on Environmental Chemicals Study (MIREC) was analysed for vascular, inflammatory and oxidative stress markers by HPLC-fluorescence, protein array and EIA method. Analysis of the <25th and >75th percentile birth weight subgroups revealed markers associated with birth weight (ETs, MMP-9, VEGF, and 8-isoPGF-2α) and gestational age (ET-1, MMP-2, and VEGF).Mechanistic insights into adverse birth outcome pathways can be achieved by integrating information on multiple biomarkers, physiology using systems biology approach.