Practical biocatalytic desymmetrization of meso-N-heterocyclic dicarboxamides and their application in the construction of aza-sugar containing nucleoside analogs.

Peng Chen, Ming Gao, De-Xian Wang, Liang Zhao, Mei-Xiang Wang

Index: Chem. Commun. (Camb.) 48(29) , 3482-4, (2012)

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Abstract

Amidase-catalyzed desymmetrization of meso-N-heterocyclic dicarboxamides under very mild conditions provided a highly efficient and practical method for the preparation of enantiomerically pure carbamoyl-substituted heterocyclic amino acids that were unique and versatile platforms for the construction of both antipodes of aza-sugar containing nucleoside analogs.This journal is © The Royal Society of Chemistry 2012