Journal of Organic Chemistry 2010-05-07

Chemoenzymatic synthesis of rivastigmine via dynamic kinetic resolution as a key step.

Kiwon Han, Cheolwoo Kim, Jaiwook Park, Mahn-Joo Kim

Index: J. Org. Chem. 75(9) , 3105-8, (2010)

Full Text: HTML

Abstract

A practical and efficient procedure for the synthesis of rivastigmine was developed. This procedure includes dynamic kinetic resolution using a polymer-bound ruthenium complex and a lipase in combination as a key step. Enantiopure (-)-rivastigmine was obtained from commercially available 3'-hydroxyacetophenone via five steps in overall 57% yield.

Related Compounds

Related Articles:

Convenient QSAR model for predicting the complexation of structurally diverse compounds with β-cyclodextrins

2009-01-01

[Bioorg. Med. Chem. 17 , 896-904, (2009)]

Virtual screening identification of nonfolate compounds, including a CNS drug, as antiparasitic agents inhibiting pteridine reductase.

2011-01-13

[J. Med. Chem. 54 , 211-221, (2011)]

Synthesis of new UV-B light absorbents: (Acetylphenyl)glycosides with antioxidant activities.

2008-06-15

[Bioorg. Med. Chem. Lett. 18 , 3582-4, (2008)]

Controlling dissociation of alkyl phenyl ketone radical cations in the strong-field regime through hydroxyl substitution position.

2014-09-18

[J. Phys. Chem. A , (2014)]

Synthesis of polyester dendrimers and dendrons starting from Michael reaction of acrylates with 3-hydroxyacetophenone. Hirayama Y, et a

[Tetrahedron Lett. 46(6) , 1027-30, (2005)]

More Articles...