Substituent effects on the stereochemistry of substituted cyclohexanone dimethylhydrazone alkylations. An x-ray crystal structure of lithiated cyclohexanone …

DB Collum, D Kahne, SA Gut, RT DePue…

Index: Collum, David B.; Kahne, Daniel; Gut, Sally A.; DePue, Randall T.; Mohamadi, Fariborz; et al. Journal of the American Chemical Society, 1984 , vol. 106, # 17 p. 4865 - 4869

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Citation Number: 41

Abstract

Conclusion It should be emphasized that the tandem Michael addition-Dieckmann condensation method shown above is extremely attractive for the construction of such a cyclopentenoid nucleus, and it makes large quantities of sarkomycin easily obtainable. Consequently, we were able to obtain good-quality NMR spectra for both sarkomycin and its ester. In addition, the method is not limited and should extend readily to other antibiotics in ...