The Aspergillus fumigatus P-type Golgi apparatus Ca2+/Mn2+ ATPase PmrA is involved in cation homeostasis and cell wall integrity but is not essential for pathogenesis.

Nadthanan Pinchai, Praveen Rao Juvvadi, Jarrod R Fortwendel, B Zachary Perfect, Luise E Rogg, Yohannes G Asfaw, William J Steinbach

Index: Eukaryotic Cell 9(3) , 472-6, (2010)

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Abstract

The Aspergillus fumigatus DeltapmrA (Golgi apparatus Ca(2+)/Mn(2+) P-type ATPase) strain has osmotically suppressible basal growth defects and cationic tolerance associated with increased expression of calcineurin pathway genes. Despite increased beta-glucan and chitin content, it is hypersensitive to cell wall inhibitors but remains virulent, suggesting a role for PmrA in cation homeostasis and cell wall integrity.