Antimicrobial Agents and Chemotherapy 2004-09-01

The AcrAB-TolC pump is involved in macrolide resistance but not in telithromycin efflux in Enterobacter aerogenes and Escherichia coli.

Renaud Chollet, Jacqueline Chevalier, André Bryskier, Jean-Marie Pagès

Index: Antimicrob. Agents Chemother. 48(9) , 3621-4, (2004)

Full Text: HTML

Abstract

The role of the AcrAB-TolC pump in macrolide and ketolide susceptibility in Escherichia coli and Enterobacter aerogenes was studied. Efflux pump inhibitor restored erythromycin, clarithromycin, and telithromycin susceptibilities to multidrug-resistant isolates. No modification of telithromycin accumulation was detected in E. aerogenes acrAB or tolC derivatives compared to that in the parental strain. Two independent efflux pumps, inhibited by phenylalanine arginine beta-naphthylamide, expel macrolides and telithromycin in E. aerogenes.

Related Compounds

Related Articles:

A novel mammalian high-molecular-weight aminopeptidase.

1997-08-01

[Arch. Biochem. Biophys. 344(1) , 228-34, (1997)]

Some ligands enhance the efflux of other ligands by the Escherichia coli multidrug pump AcrB.

2013-11-19

[Biochemistry 52(46) , 8342-51, (2013)]

Enzymatic reactions of Clostridium difficile in aerobic and anaerobic environments with the RapID-ANA II identification system.

1993-02-01

[J. Clin. Microbiol. 31(2) , 279-82, (1993)]

Subcellular distribution of soluble and membrane-bound Leu-, Arg- and Asp-beta-naphthylamide-hydrolysing activities in rat brain.

[Cell Mol. Biol. 36(2) , 175-9, (1990)]

Characterization of the quinolone resistance mechanism in foodborne Salmonella isolates with high nalidixic acid resistance.

2011-03-15

[Int. J. Food Microbiol. 146(1) , 52-6, (2011)]

More Articles...