Rational Design, Synthesis, and DNA Binding Properties of Novel Sequence??Selective Peptidyl Congeners of Ametantrone

A Gianoncelli, S Basili, M Scalabrin, A Sosic…

Index: Gianoncelli, Alessandra; Basili, Serena; Scalabrin, Matteo; Sosic, Alice; Moro, Stefano; Zagotto, Giuseppe; Palumbo, Manlio; Gresh, Nohad; Gatto, Barbara ChemMedChem, 2010 , vol. 5, # 7 p. 1080 - 1091

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Citation Number: 10

Abstract

Abstract Natural and synthetic compounds characterized by an anthraquinone nucleus represent an important class of anti-neoplastic agents, the mechanism of action of which is related to intercalation into DNA. Ametantrone (AM) is a synthetic 9, 10-anthracenedione bearing two (hydroxyethylamino) ethylamino residues at positions 1 and 4; along with other anthraquinones and anthracyclines, it shares a polycyclic intercalating moiety and ...