Synthesis and Reactions of Glycidonitriles. Transformation into α-Haloacyl Compounds and Aminoalcohols

G Stork, WS Worrall, JJ Pappas

Index: Stork,G. et al. Journal of the American Chemical Society, 1960 , vol. 82, p. 4315 - 4323

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Citation Number: 34

Abstract

Studies in this Laboratory on the Favorskir rearrangement'made it quite clear that the synthesis of haloketones of type I (R1, Rp, RE= H or alkyl) is not at present very satisfactory. Direct halogenation of the parent ketone (cf. 11) suffers from two major drawbacks: It is necessary to utilize a source of positive halogen which may not be compatible with the presence of certain functional groups in the molecule (eg, double bonds, phenolic rings), ...