Arylamine N-acetyltransferase responsible for acetylation of 2-aminophenols in Streptomyces griseus.

Hirokazu Suzuki, Yasuo Ohnishi, Sueharu Horinouchi

Index: J. Bacteriol. 189(5) , 2155-9, (2007)

Full Text: HTML

Abstract

An arylamine N-acetyltransferase (NAT) responsible for the N acetylation of exogenous 3-amino-4-hydroxybenzoic acid in Streptomyces griseus was identified and characterized. This enzyme was distinct from other eukaryotic and bacterial NATs in that it acetylated various 2-aminophenol derivatives more effectively than it acetylated 5-aminosalicylic acid, and thus it may be involved in the metabolism of xenobiotic compounds.