In vitro metabolism of chloroprene: species differences, epoxide stereochemistry and a de-chlorination pathway

…, BT Golding, T Munter, WP Watson

Index: Cottrell; Golding; Munter; Watson Chemical Research in Toxicology, 2001 , vol. 14, # 11 p. 1552 - 1562

Full Text: HTML

Citation Number: 31

Abstract

Chloroprene (1) was metabolized by liver microsomes from Sprague-Dawley rats, Fischer 344 rats, B6C3F1 mice, and humans to the monoepoxides,(1-chloro-ethenyl) oxirane (5a/5b), and 2-chloro-2-ethenyloxirane (4a/4b). The formation of 4a/4b was inferred from the identification of their degradation products. With male Sprague-Dawley and Fischer 344 rat liver microsomes, there was a ca. 3: 2 preference for the formation of (R)-(1-chloroethenyl) ...