[Absorption of C14-labeled dye "active red 5CX"++ immobilized on polysaccharides in the rat gastrointestinal tract].

G N Shatrov, I V Gmoshinskiĭ, A N Zaĭtsev

Index: Vopr. Med. Khim. 35(1) , 95-9, (1989)

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Abstract

Rats were maintained on a diet containing 14C-aniline procion dye "active red 5CX" either in a hydrolyzed or chemically immobilized form on starch and cellulose. Absorption of the label, distribution in tissues and excretion were studied within 6-48 hrs. Independently on the forms of the preparation used more than 80% of the label occurred in blood and were then excreted with urine. Molecule of the azo-dye appears to degrade in large intestine by means of microflora with splitting of the azo-bond and the potentially toxic metabolites developed penetrated into a body media. Immobilization of the dye on polymers, including cellulose was not an effective approach to prevent these reactions.