Bioorganic & Medicinal Chemistry Letters 2005-01-17

Synthesis and SAR of novel 4,5-diarylimidazolines as potent P2X7 receptor antagonists.

Gregory H Merriman, Liang Ma, Patrick Shum, Daniel McGarry, Frank Volz, Jeffrey S Sabol, Alexandre Gross, Zhicheng Zhao, David Rampe, Lin Wang, Friederike Wirtz-Brugger, Bruce A Harris, Douglas Macdonald

Index: Bioorg. Med. Chem. Lett. 15(2) , 435-8, (2005)

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Abstract

A series of 4,5-diarylimidazoline libraries were prepared using high-throughput solid-phase and microwave techniques. The compounds were evaluated as P2X(7) antagonists and their SAR is described.