Tetrahedron

A simple and efficient method for the synthesis of Erlenmeyer azlactones

PA Conway, K Devine, F Paradisi

Index: Conway, Philip A.; Devine, Kevin; Paradisi, Francesca Tetrahedron, 2009 , vol. 65, # 15 p. 2935 - 2938

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Citation Number: 41

Abstract

We have recently developed a novel and efficient method for synthesising Erlenmeyer azlactones under mild and rapid conditions. The reaction is performed by reacting 2-phenyl- 5-oxazolone with an aldehyde in dichloromethane using alumina as a catalyst. The materials react instantly at room temperature, negating the need for high temperatures and long reaction times. We have successfully used this method for both aliphatic, aromatic ...