Determination of oxeladin in human plasma by gas chromatography--mass spectrometry.

C Lartigue-Mattei, M J Galmier, J L Chabard, E Beyssac, J M Aiache

Index: Biomed. Chromatogr. 9(1) , 32-5, (1995)

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Abstract

A capillary gas chromatographic method with mass-selective detection was developed for the determination of oxeladin in human plasma. Plasma samples (1 mL) were alkalinized and extracted using 5mL of hexane: isoamyl alcohol (99:1). The method was demonstrated to be sensitive (limit of quantitation at 1 ng/mL), linear between 1 and 150 mg/mL, accurate and precise enough (mean error and mean coefficient of variation at the limit of quantitation were 2.3 and 13.3%, respectively) to support pharmacokinetic evaluation of the drug at doses down to 30 mg.