An improved method for the rapid preparation of 2-amino-4,4a-dihydro-4a,7-dimethyl-3H-phenoxazine-3-one, a novel antitumor agent.
A Tomoda, S Arai, R Ishida, T Shimamoto, K Ohyashiki
Index: Bioorg. Med. Chem. Lett. 11(8) , 1057-8, (2001)
Full Text: HTML
Abstract
A simple and rapid preparation method for a novel antitumor agent, 2-amino-4,4a-dihydro-4a,7-dimethyl-3H-phenoxazine-3-one (Phx) was described. The procedure included (1) the reaction of bovine hemolysates with 2-amino-5-methylphenol, (2) one-shot denaturation of hemoglobin and proteins by methanol, and removal of the denatured hemoglobin and proteins, (3) concentration of the reaction products, and (4) purification by a Sephadex column. These procedures yielded Phx in 34% yield.
Related Compounds
Related Articles:
2000-12-01
[Tohoku J. Exp. Med. 192(4) , 301-12, (2000)]
Antiviral activity of 2-amino-4,4alpha-dihydro-4alpha-7-dimethyl-3H-phenoxazine-3-one on poliovirus.
2003-07-01
[Tohoku J. Exp. Med. 200(3) , 161-5, (2003)]
Phenoxazinone synthesis by human hemoglobin.
1992-10-27
[Biochim. Biophys. Acta 1117(3) , 306-14, (1992)]
2007-06-01
[Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 67(2) , 550-8, (2007)]
Synthesis,structural characterization and catalytic activity study of Mn(II), Fe(III), Ni(II), Cu(II) and Zn(II) complexes of quinoxaline-2-carboxalidine-2-amino-5-methylphenol: Crystal structure of the nickel (II) complex. Sebastian M, et al.
[Polyhedron 29(15) , 3014-3020, (2010)]