Three-step synthesis of an array of substituted benzofurans using polymer-supported reagents

J Habermann, SV Ley, R Smits

Index: Habermann, Joerg; Ley, Steven V.; Smits, Rene Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 17 p. 2421 - 2423

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Citation Number: 96

Abstract

An efficient combinatorial route to substituted 3-phenylbenzofurans, is achieved by the bromination of acetophenones to α-bromoacetophenones by polymer-supported pyridinium bromide perbromide (PSPBP). The subsequent clean substitution of the obtained bromides by phenols using 1, 5, 7-triazabicyclo [4.4. 0] dec-5-ene (TBD-P) and cyclodehydration of the resulting α-phenoxyacetophenones using Amberlyst 15, affords pure products without the ...