A novel synthesis of 1, 4-dihydrobenzo [c]-1, 5-naphthyridin-2 (3H)-ones from pyrrolo [1, 2-b] isoquinolines

…, SJ Scott, MN Agnew, LL Setescak

Index: Martin, Lawrence L.; Scott, Susan J.; Agnew, Marc N.; Setescak, Linda L. Journal of Organic Chemistry, 1986 , vol. 51, # 19 p. 3697 - 3700

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Citation Number: 19

Abstract

While investigating the synthesis of hydroxy-and amino-substituted pyrrole [1, 2-b] isoquinolines (Scheme I, 4?, 1, Cdihydrobenzo [c]-1, 5-naphthyridin-2 (3H)-one (6a) was obtained as the exclusive product from an attempted Beckmann rearrangement of 3a. Although partially reduced benzo [c]-1, 5-naphthyidines (eg, 5, 6-dihydr0-~ and 5, 6, 6a, 7, 8, 9, 10, 10a-octahydrobenzo [c]-l, 5-naphth~ idine4) are known, the reported syntheses do ...