Homolytic Substitution and Carbenoidic Reactions in the Preparation of Benzimidazole Derivatives of Pharmaceutical Interest: Synthesis and Properties of (2?? …

R Pellicciari, R Fringuelli, B Natalini…

Index: Pellicciari; Fringuelli; Natalini; Brucato; Contessa Archiv der Pharmazie, 1985 , vol. 318, # 5 p. 393 - 399

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Citation Number: 5

Abstract

Abstract The preparation and preliminary biological evaluation of the (2-cycloalkyl-1- benzimidazolyl)-N, N-diethylacetamides 7a–e are described. Key steps for the preparation of the compounds 7a–d are (i) the homolytic cycloalkylation of benzimidazole, in which the silver-catalyzed oxidative decarboxylation of the cycloalkanecarboxylic acids 1a–d by peroxydisulfate is used as a source of alkyl radicals, and (ii) the N-alkylation of ...