Medicinal Chemistry Research

Synthesis and antidepressant-like action of N-(2-hydroxyethyl) cinnamamide derivatives in mice

XQ Deng, D Wu, CX Wei, ZS Quan

Index: Deng, Xian-Qing; Wu, Di; Wei, Cheng-Xi; Quan, Zhe-Shan Medicinal Chemistry Research, 2011 , vol. 20, # 8 p. 1273 - 1279

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Citation Number: 7

Abstract

Abstract This study described the chemical synthesis and pharmacological evaluation of a series of N-(2-hydroxyethyl) cinnamamide derivatives. The structures of them were characterized by IR, 1 H-NMR, MS and elemental analysis. Their antidepressant activities were evaluated by the forced swimming test (FST) and tail suspension test (TST). Pharmacological results of these compounds showed that some of them, given orally, ...