Synthesis, anti-inflammatory activity, and QSAR study of some Schiff bases derived from 5-mercapto-3-(4′-pyridyl)-4H-1, 2, 4-triazol-4-yl-thiosemicarbazide

H Sachdeva, D Dwivedi, K Arya, S Khaturia…

Index: Sachdeva, Harshita; Dwivedi, Diksha; Arya, Kapil; Khaturia, Sarita; Saroj, Rekha Medicinal Chemistry Research, 2013 , vol. 22, # 10 p. 4953 - 4963

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Citation Number: 5

Abstract

Abstract The purpose of this research is to synthesize better anti-inflammatory compounds derived from 5-mercapto-3-(4′-pyridyl)-4 H-1, 2, 4-triazol-4-yl-thiosemicarbazide (5). 2- Substituted-N-[3-(pyridin-4-yl)-5-sulfanyl-4 H-1, 2, 4-triazol-4-yl] hydrazine carbothioamide derivatives (6a–j)/(7a–e) are synthesized by the condensation of 5 with variously substituted aromatic aldehydes/1 H-indole-2, 3-diones, respectively, under conventional and ...