C (10)??Methylation of Steroidal Synthesis Intermediate BCD??Tricyclic 9??En??5??ones

…, P Buchschacher, L Labler, W Meier…

Index: Scott; Buchschacher; Labler; Meier; Fuerst Helvetica Chimica Acta, 1974 , vol. 57, # 4 p. 1217 - 1233

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Citation Number: 6

Abstract

Abstract A literature survey indicated that stereospecific non-reductive β-face methylation at C (10) of steroidal synthesis intermediate BCD-tricyclic 9-en-5-ones had never been effected. An attempt to define the factors controlling the β/α product ratio in such alkylations was made. The course of methylation is significantly affected by the temperature. In the best case, methylation of the sodium enolate of 17 β-t-butoxy-19-(3, 5-dimethyl-4-isoxazolyl)- ...