Synergistic effect of dual-frequency ultrasound irradiation in the one-pot synthesis of 3, 5-disubstituted isoxazoles
M Koufaki, T Fotopoulou, GA Heropoulos
Index: Koufaki, Maria; Fotopoulou, Theano; Heropoulos, Georgios A. Ultrasonics Sonochemistry, 2014 , vol. 21, # 1 p. 35 - 39
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Citation Number: 11
Abstract
Abstract Herein is reported a one-pot three-step process for the regioselective synthesis of 3, 5-disubstituted isoxazoles based on copper (I)-catalyzed cycloaddition reaction between in situ generated nitrile oxides (from the corresponding aldehydes) and alkynes, using ultrasound irradiation, avoiding toxic reagents and solvents and isolation/purification of intermediates.
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