Simultaneous determination of hydroxyzine hydrochloride and benzyl alcohol in injection solutions by high-performance liquid chromatography.
G N Menon, B J Norris
Index: J. Pharm. Sci. 70(6) , 697-8, (1981)
Full Text: HTML
Abstract
A stability-indicating, high-performance liquid chromatographic method was developed for the simultaneous determination of hydroxyzine hydrochloride and benzyl alcohol in injection solutions. Separation was achieved using a mu Bondapak C18 column and the eluent [60% water, 25% acetonitrile, and 15% methanol containing 0.06% (v/v) sulfuric acid, 0.5% (w/v) sodium sulfate, and 0.02% (w/v) heptanesulfonic acid sodium salt] at a flow rate of 2 ml/min. Isobutyrophenone and p-nitroacetophenone were used as internal standards. The UV detector response at 257 nm was linear for hydroxyzine hydrochloride in the 3--10-mg/ml range and for benzyl alcohol in the 0.54--1.8 mg/ml range under analysis conditions. The method is accurate, simple, and precise.
Related Compounds
Related Articles:
2015-08-01
[Tissue Eng. Part C Methods 21 , 773-85, (2015)]
2015-01-01
[Cell J. 17 , 478-88, (2015)]
3D cardiac microtissues encapsulated with the co-culture of cardiomyocytes and cardiac fibroblasts.
2015-09-16
[Adv. Healthc. Mater. 4 , 1961-71, (2015)]
The chlorination of isobutyrophenone: determination of its p K a value and of the course of the reaction. Guthrie JP and Cossar J.
[Can. J. Chem. 68(3) , 397-403, (1990)]