Synthesis and biological evaluation of substituted flavones as gastroprotective agents

…, JL Randall, PD Murray, PS Weisshaar…

Index: Ares, Jeffrey J.; Outt, Pamela E.; Randall, Jared L.; Murray, Peter D.; Weisshaar, Pamela S.; et al. Journal of Medicinal Chemistry, 1995 , vol. 38, # 25 p. 4937 - 4943

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Citation Number: 55

Abstract

Flavone (1) was found to protect against ethanol-induced gastric damage in rats; however, it is known that certain compounds in the flavone class, including flavone itself, are inducers of hepatic drug metabobizing enzymes. With the hope of identifying gastroprotective flavones that have minimal effects on drug metabolizing enzymes, we have synthesized and evaluated selected flavone analogs. Gastroprotective potency in the ethanol model was ...